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- Title
Immunoelectron Microscopy of Type III Collagen in Normal and Scleroderma Skin.
- Authors
Fleischmajer, Raul; Gay, Steffen; Perlish, Jerome S.; Cesarini, Jean-Pierre
- Abstract
Normal and scleroderma skin was studied by indirect immuno-electron microscopy with specific antibodies against Type III collagen. Fine collagen fibrils, 200-400 Å in diameter were labeled with antitype III collagen antibodies. These antibodies attached to the collagen fibril forming rings with a 650 Å periodicity. Fibrils with more than 600 Å in diameter were only labeled with antitype I collagen antibodies. Type III collagen was found around small blood vessels, adipocytes and smooth muscle cells, thus, corresponding to the distribution of reticulin.
- Subjects
ELECTRON microscopy; SCLERODERMA (Disease); COLLAGEN; BLOOD circulation; IMMUNOGLOBULINS; FAT cells
- Publication
Journal of Investigative Dermatology, 1980, Vol 75, Issue 2, p189
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12522644