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- Title
ENZYMATIC BASIS FOR THE ACTIVE TRANSPORT OF SODIUM IN THE ECCRINE SWEAT GLAND.
- Authors
Sato, Kenzo; Dobson, Richard L.; Mali, J. W. H.
- Abstract
1. The characteristics of the Na-K-ATPase of the rhesus monkey palm eccrine sweat gland were studied. The maximal activation concentrations for Na+ and K+ were 200 mM and 40 mM respectively. 2. An attempt was made to estimate the stoichiometric relationship between Na+ flux and ATP hydrolysis by the Na-K-ATPase activity obtained in this study and ATP production estimated from CO2 and lactate production reported in our previous paper (1). Na+/ATP ratios of 3.3 and 3.0 respectively were obtained, which agree well with the usual ratio of 3 found in other transporting epithelia. 3. The distal (straight) duct was isolated and its Na-K-ATPase activity determined. The Na-K-ATPase activity in the distal duct was less than one tenth of that in the sweat gland coil (secretory coil + proximal duct) and thus the role of the distal duct as a site of active sodium transport would be relatively minor.
- Subjects
ENZYME activation; SWEAT glands; ADENOSINE triphosphatase; RHESUS monkeys; STOICHIOMETRY; LACTATES
- Publication
Journal of Investigative Dermatology, 1971, Vol 57, Issue 1, p10
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12292046