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- Title
Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time.
- Authors
Lasho, Terra L.; Pardanani, Animesh; McClure, Rebecca F.; Mesa, Ruben A.; Levine, Ross L.; Gary Gilliland, D.; Tefferi, Ayalew
- Abstract
MPLW515L/K and JAK2V617F can co-exist in myelofibrosis with myeloid metaplasia (MMM).The chronology of clonal emergence was studied in three such cases using serially stored bone marrow. At diagnosis, a major MPL515 mutant clone was accompanied by a minor JAK2V617F clone in all three instances. At 25 time points over a period of 4–8 years, allele burden fluctuated but remained high for MPLW515L/K and low for JAK2V617F. We conclude that MPLW515L/K and JAK2V617F are both early events in MMM and allele burden, rather than the mere presence of these mutations, might be relevant to phenotypic variation in myeloproliferative disorders.
- Subjects
MYELOFIBROSIS; GENETIC mutation; MYELOPROLIFERATIVE neoplasms; BONE marrow diseases; MYELOID metaplasia
- Publication
British Journal of Haematology, 2006, Vol 135, Issue 5, p683
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2006.06348.x