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- Title
SMALL INTESTINAL CARCINOMA WITH OSTEOCLAST-LIKE GIANT CELLS.
- Authors
Odeh, Majed; Misselevich, Ines; Oliven, Arie; Boss, Jochanan H.
- Abstract
An elderly woman underwent jejunectomy for a large, stenosing neoplasm. Histologically, we found an undifferentiated carcinoma with scattered mononuclear and multinuclear macrophages in the intestine and lymph node metastases. The multinuclear cells, being acid phosphatase-positive and CD68-immunoceactive, are referred to as osteoclast-like giant cells. Hepatic secondaries were discovered 6 months postoperatively. The patient succumbed to a chemotherapy-related septic event. We suggest that intratumoral infiltration by mononuclear and multinuclear macrophages expresses one of the body's defense mechanisms against cancer.
- Subjects
JEJUNOILEAL bypass; TUMOR surgery; DISEASES in older women; MACROPHAGES; LYMPH nodes; METASTASIS
- Publication
American Journal of Gastroenterology (Springer Nature), 1995, Vol 90, Issue 7, p1177
- ISSN
0002-9270
- Publication type
Article