We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.
- Authors
Finkelstein, Joel S; Lee, Hang; Karlamangla, Arun; Neer, Robert M; Sluss, Patrick M; Burnett-Bowie, Sherri-Ann M; Darakananda, Karin; Donahoe, Patricia K; Harlow, Sioban D; Prizand, Sarah H; Joffe, Hadine; Kumar, Ajay; Martin, Deborah E; McConnell, Daniel; Merrilat, Steffenie; Morrison, Anthony; Pastore, Lisa M; Randolph, John F; Greendale, Gail A; Santoro, Nanette
- Abstract
<bold>Background: </bold>A test that helps predict the time to the final menstrual period (FMP) has been sought for many years.<bold>Objective: </bold>To assess the ability of antimullerian hormone (AMH) measurements to predictions the time to FMP.<bold>Design: </bold>Prospective longitudinal cohort study.<bold>Setting: </bold>The Study of Women's Health Across the Nation.<bold>Participants and Measurements: </bold>AMH and FSH were measured in 1537 pre- or early perimenopausal women, mean age 47.5 ± 2.6 years at baseline, then serially until 12 months of amenorrhea occurred. AMH was measured using a 2-site ELISA with a detection limit of 1.85 pg/mL.<bold>Main Outcome Measure: </bold>Areas under the receiver operating curves (AUC) for AMH-based and FSH-based predictions of time to FMP, stratified by age. Probabilities that women would undergo their FMP in the next 12, 24, or 36 months across a range of AMH values were assessed.<bold>Results: </bold>AUCs for predicting that the FMP will occur within the next 24 months were significantly greater for AMH-based than FSH-based models. The probability that a woman with an AMH <10 pg/mL would undergo her FMP within the next 12 months ranged from 51% at h<48 years of age to 79% at ≥51 years. The probability that a woman with an AMH >100 pg/mL would not undergo her FMP within the next 12 months ranged from 97% in women <48 years old to 90% in women ≥51 years old.<bold>Conclusions: </bold>AMH measurement helps estimate when a woman will undergo her FMP, and, in general, does so better than FSH.
- Subjects
WOMEN'S health; WOMEN'S studies; POSTMENOPAUSE; MENOPAUSE; OLDER women; CLIMACTERIC; DETECTION limit; PREMATURE menopause
- Publication
Journal of Clinical Endocrinology & Metabolism, 2020, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgz283