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- Title
The Lyophilization Process Maintains the Chemical and Biological Characteristics of Royal Jelly.
- Authors
Piacezzi Nascimento, Andresa; Roveroni Moraes, Larissa Ariana; Ursoli Ferreira, Nathália; de Padua Moreno, Gabriela; Mangolini Uahib, Fernanda Grassi; Aparecida Barizon, Edna; Aparecida Berretta, Andresa
- Abstract
The alternative use of natural products, like royal jelly (RJ), may be an important tool for the treatment of infections caused by antibiotic-resistant bacteria. RJ presents a large number of bioactive substances, including antimicrobial compounds. In this study, we carried out the chemical characterization of fresh and lyophilized RJ and investigated their antibacterial effects with the purpose of evaluating if the lyophilization process maintains the chemical and antibacterial properties of RJ. Furthermore, we evaluated the antibacterial efficacy of the main fatty acid found in RJ, the 10-hydroxy-2-decenoic acid (10H2DA). Chromatographic profile of the RJ samples showed similar fingerprints and the presence of 10H2DA in both samples. Furthermore, fresh and lyophilized RJ were effective against all bacteria evaluated; that is, the lyophilization process maintains the antibacterial activity of RJ and the chemical field of 10H2DA. The fatty acid 10H2DA exhibited a good antibacterial activity against Streptococcuspneumoniae. Therefore, it may be used as an alternative and complementary treatment for infections caused by antibiotic-resistant S. pneumoniae.
- Subjects
BRAZIL; ALTERNATIVE medicine; ANALYSIS of variance; ANTI-infective agents; CHROMATOGRAPHIC analysis; FATTY acids; GRAM-negative bacteria; GRAM-positive bacteria; RESEARCH funding; DESCRIPTIVE statistics; IN vitro studies
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, p1
- ISSN
1741-427X
- Publication type
journal article
- DOI
10.1155/2015/825068