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- Title
Genetics of premature ovarian failure.
- Authors
Tolunay, Harun Egemen; Boza, Barış; Varlı, Bulut
- Abstract
Premature ovarian failure was defined as the cut -off of menstrual period for at least 4-6 months before 40 years of age, and FSH values measured over a month were over 40 IU/L. Although etiology is not fully understood, it is thought that genetic, immunological and environmental factors can play a role. Nowadays, translational and deletion in the critical regions (Xq13-26) on the X chromosome are defined in the developmental light in the genetic area. New approaches have been developed in clinical follow-up and treatment in recent years. It has been reported that caution should be taken in the follow-up, especially in terms of osteoporosis. In this article, recent literature on premature ovarian failure attempted to reveal current genetic etiology of premature ovarian failure.
- Subjects
PREMATURE ovarian failure; X chromosome abnormalities; MENSTRUAL cycle; ETIOLOGY of diseases; DELETION mutation; GENETICS
- Publication
Eastern Journal of Medicine, 2018, Vol 23, Issue 2, p135
- ISSN
1301-0883
- Publication type
Article
- DOI
10.5505/ejm.2018.14622