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- Title
Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study.
- Authors
Bi, DeWu; Chen, ZhenCheng; Wei, ShanQiu; Xie, ZhouHua; Zang, Ning; Mo, LiDa; Liu, ZeDuan; Wang, YuanLi; Cao, LiangLi; Zhao, FeiJun; Lin, YanRong; Qin, YaQin; Tang, XiKe; Su, HanZhen; Zhou, JinAi; Liang, JuanYing; Lan, ZhenXu; Lin, Lü; Xi, ShaoYong; Luo, XiaoCheng
- Abstract
Background. Coronavirus disease 2019 (COVID-19) is a potentially fatal pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially those of novel SARS-CoV-2 variants and infection has affected over 700 million people globally. Methods. This retrospective, descriptive study included 118 patients admitted with SARS-CoV-2 infection as confirmed by real-time reverse transcription polymerase chain reaction. Results. The median duration of detectable SARS-CoV-2 infection in patients with high ALT, AST, and PLT/LYMPH, or low CD4+, CD8+, and PLT/MONO was considerably longer. In the risk factor model, multivariate analysis was performed for the estimation of ALT (HR, 0.54; 95% CI, 0.36-0.81), AST (HR, 0.56; 95% CI, 0.34-0.93), CD4+ (HR,0.77; 95% CI, 0.48-1.24), CD8+ (HR,0.64; 95% CI, 0.37-1.11), PLT/LYMPH (HR, 1.16; 95% CI, 0.76-1.77), and PLT/MONO (HR, 0.64; 95% CI, 0.43-0.94). Conclusions. The longer viral RNA duration was associated with a higher International Prognostic Index score (p = 0.0013), demonstrating for the first time that multivariate features of the bioindicators closely associated with SARS-CoV-2-infected patients clear the virus.
- Subjects
PUBLIC health surveillance; REVERSE transcriptase polymerase chain reaction; COVID-19; CONFIDENCE intervals; PLATELET lymphocyte ratio; RESEARCH methodology; MULTIVARIATE analysis; RNA; RETROSPECTIVE studies; DISEASE duration; DESCRIPTIVE statistics; LONGITUDINAL method; ALANINE aminotransferase; ASPARTATE aminotransferase
- Publication
BioMed Research International, 2022, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2022/1399268