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- Title
Evolution of the vestibular function during head impulses in spinocerebellar ataxia type 6.
- Authors
Lee, Sun-Uk; Kim, Ji-Soo; Kim, Hyo-Jung; Choi, Jeong-Yoon; Park, Ji-Yun; Kim, Jong-Min; Yang, Xu
- Abstract
Evolution of vestibular function requires further elucidation in spinocerebellar ataxia (SCA). This study aimed to determine temporal evolution in the findings of head impulse tests (HITs) in SCA type 6 (SCA6). We serially evaluated HITs in 12 patients with SCA6 using video-oculography for 3 months to 5 years [median = 12 months, interquartile range (IQR) = 9–50] at two university hospitals in South Korea. Patients (8/12, 67%) usually showed abnormal responses at least for one semicircular canal during video-HITs. The gains of the vestibulo-ocular reflex (VOR) for the anterior canals (ACs) were larger than those for the posterior canals (PCs, p = 0.005) at initial presentation. During the follow-up, the VOR gains decreased for the horizontal canals (HCs, p = 0.008) and ACs (p = 0.021), but those for the PCs remained unchanged (p = 0.212). Perverted HITs were observed in seven patients (7/12, 58%). The differences in the head impulse VOR gains were larger between the ACs and PCs (ΔACs − PCs) in those with perverted HITs than in those without (p = 0.003). The gains for each semicircular canal showed a negative correlation with the Scale for the Assessment and Rating of Ataxia (HCs, Spearman's coefficient = − 0.675, p = 0.003; ACs, − 0.637, p = 0.006; PCs, − 0.605, p = 0.010). The head impulse gain of the VOR may serve a marker for clinical decline in SCA6. The dissociation in the temporal evolution of the VOR gain indicates dissimilar cerebellar modulation of the vestibular signals from each semicircular canal.
- Subjects
SOUTH Korea; SPINOCEREBELLAR ataxia; SEMICIRCULAR canals; VESTIBULO-ocular reflex; RANK correlation (Statistics); BIOLOGICAL evolution
- Publication
Journal of Neurology, 2020, Vol 267, Issue 6, p1672
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-020-09756-w