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- Title
Development of a Bedside Tool to Predict the Diagnosis of Cerebral Palsy in Term-Born Neonates.
- Authors
Rouabhi, Amira; Husein, Nafisa; Dewey, Deborah; Letourneau, Nicole; Daboval, Thierry; Oskoui, Maryam; Kirton, Adam; Shevell, Michael; Dunbar, Mary J.
- Abstract
Key Points: Question: Can a prognostic tool for the occurrence of cerebral palsy (CP) in all term neonates be developed from easily obtainable variables pertaining to the pregnancy, delivery, and neonate? Findings: This case-control study of potential CP risk factors including 1265 individuals with CP and 1985 controls demonstrated that risk factors are additive. The prognostic tool had a sensitivity and specificity for CP of 56% and 82%, respectively, which identified twice as many children with CP than if just encephalopathy was considered. Meaning: In this study, a simple prognostic tool using 12 variables identified term infants at risk of developing CP who may lack a classic risk factor, such as encephalopathy. This case-control study evaluates a cerebral palsy prognostic tool that can be applied to all term neonates to identify those at increased risk of developing cerebral palsy. Importance: Cerebral palsy (CP) is the most common abnormality of motor development and causes lifelong impairment. Early diagnosis and therapy can improve outcomes, but early identification of infants at risk remains challenging. Objective: To develop a CP prognostic tool that can be applied to all term neonates to identify those at increased risk of developing CP. Design, Setting, and Participants: This case-control study used data from the Canadian Cerebral Palsy Registry (data collected from January 2003 to December 2019) for children with CP and the Alberta Pregnancy Outcomes and Nutrition study (mothers enrolled from May 2009 to September 2012; data extracted in 2020) for controls. There were 2771 children with CP and 2131 controls evaluated; 941 and 144, respectively, were removed for gestational age less than 37 weeks at birth, 565 with CP removed for incomplete data, and 2 controls removed for a diagnosis of CP. Data were analyzed from April to August 2022. Exposures: Potential risk factors were selected a priori based on the literature, including maternal, intrapartum, and infant characteristics. Main Outcomes and Measures: Diagnosis of CP, defined as a disorder of motor function due to a nonprogressive brain abnormality before age 1 year and classified by Gross Motor Function Classification System levels I to V. Results: Of 3250 included individuals, 1752 (53.9%) were male, and the median (IQR) gestational age at birth was 39 (38-40) weeks. Encephalopathy was present in 335 of 1184 infants with CP (28%) and 0 controls. The final prediction model included 12 variables and correctly classified 75% of infants, with a sensitivity of 56% (95% CI, 52-60) and specificity of 82% (95% CI, 81-84). The C statistic was 0.74 (95% CI, 71-76). Risk factors were found to be additive. A proposed threshold for screening is probability greater than 0.3, with a sensitivity of 65% (95% CI, 61-68) and specificity of 71% (95% CI, 69-73). The prognostic tool identified 2.4-fold more children with CP than would have presented with encephalopathy (odds ratio, 13.8; 95% CI, 8.87-22.65; P <.001). Conclusions and Relevance: In this case-control study, a prognostic model using 12 clinical variables improved the prediction of CP compared with clinical presentation with encephalopathy. This tool can be applied to all term newborns to help select infants for closer surveillance or further diagnostic tests, which could improve outcomes through early intervention.
- Subjects
CONFIDENCE intervals; POINT-of-care testing; CASE-control method; DESCRIPTIVE statistics; CEREBRAL palsy; PREDICTION models; CHILDREN
- Publication
JAMA Pediatrics, 2023, Vol 177, Issue 2, p177
- ISSN
2168-6203
- Publication type
Article
- DOI
10.1001/jamapediatrics.2022.5177