We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Las endotelinas (Et) en la hipertensión arterial.
- Authors
Carbajal Rodríguez, Luis; Rodríguez Herrera, Raymundo; Zarco Román, Jorge; Perea Martínez, Arturo; Copto García, Alfonso
- Abstract
Of the group of vasoactive substances in the organism, the endothelins seem to have special importance in the physiology of cardiovascular diseases. Of these, the most studied is Et1. It is an autochrine hormone that could increase arterial pressure for being a powerful vasoconstrictor which is 100 times higher than the norepinephrin and 10 times higher than the angiotensin II. It is synthesized in the vascular endothelium and the smooth muscle. It is activated by vasoactive substances, hypoxia and vascular stress. The endothelins participate as modulators of vascular tone, celular proliferation and hormonal production. There are three kinds of Et: Et1, Et2, and Et3. The receptors of these kinds of Et3 are two: Eta and Etb. These receptors have three isoforms of endothelin converting enzymes as ECE1a, ECE1b and ECE1c. In the face of endothelial dysfunction due to risk factors the vasoconstriction functions are activated especially the Et1.
- Subjects
HYPERTENSION; THERAPEUTICS; ENDOTHELINS; VASOCONSTRICTORS; ARTERIAL diseases; NORADRENALINE; VASCULAR endothelium; HORMONES; CELL proliferation
- Publication
Revista Mexicana de Pediatria, 2013, Vol 80, Issue 4, p150
- ISSN
0035-0052
- Publication type
Article