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- Title
Blastocystis hominis and Dientamoeba fragilis in patients fulfilling irritable bowel syndrome criteria.
- Authors
Yakoob, Javed; Jafri, Wasim; Beg, Mohammad; Abbas, Zaigham; Naz, Shagufta; Islam, Muhammad; Khan, Rustam
- Abstract
Studies have suggested a possible role for Blastocystis hominis and Dientamoeba fragilis in the etiology of irritable bowel syndrome (IBS). We studied the prevalence of B. hominis and D. fragilis in patients with IBS-diarrhea (IBS-D). Three hundred and thirty patients were enrolled, 171 (52%) with IBS-D and 159 (48%) were controls, respectively. Stool microscopy, culture, and polymerase chain reaction (PCR) for B. hominis and D. fragilis were done. B. hominis was positive by stool microscopy in 49% (83/171) of IBS compared to 24% (27/159) in control ( p < 0.001). B. hominis culture was positive in 53% (90/171) in IBS compared to 16% (25/159) in control ( p < 0.001). B. hominis PCR was positive in 44% (75/171) in IBS compared to 21% (33/159) in control ( p < 0.001). D. fragilis microscopy was positive in 3.5% (6/171) in IBS-D compared to 0.6% (1/159) in control ( p = 0.123). D. fragilis culture was positive in 4% (7/171) in IBS compared to 1.3% (2/159) in control ( p = 0.176). D. fragilis PCR was positive in 4% (6/171) in IBS-D compared to 0% (0/159) in control ( p = 0.030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR.
- Subjects
IRRITABLE colon; ETIOLOGY of diseases; BLASTOCYSTIS; ENTAMOEBA; POLYMERASE chain reaction; MICROSCOPY; CONTROL groups
- Publication
Parasitology Research, 2010, Vol 107, Issue 3, p679
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-010-1918-7