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- Title
Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on pathological and biological characteristics of tumor cells.
- Authors
Omori, Tomokazu; Aokage, Keiju; Nakamura, Hiroshi; Katsumata, Shinya; Miyoshi, Tomohiro; Sugano, Masato; Kojima, Motohiro; Fujii, Satoshi; Kuwata, Takeshi; Ochiai, Atsushi; Ikeda, Norihiko; Tsuboi, Masahiro; Ishii, Genichiro
- Abstract
Purpose: The growth pattern of peripheral squamous cell carcinoma (SCC) of the lung is divided into two types: alveolar space-filling (ASF) growth and alveolar space-destructive (ASD) growth. The aim of this study was to investigate the clinicopathological differences between cancer cells displaying ASF and ASD growth. Methods: We analyzed 155 patients with peripheral SCC measuring 30 mm or less in diameter. The proportion of ASF in the total tumor area (%ASF) was determined using digital image analysis. We examined the clinicopathological characteristics of the cancer cells and compared the immunophenotypes of high %ASF tumors (> 30%) and low %ASF tumors (0%). Finally, we analyzed the prognostic impact of ASD area with small SCC cases (≤ 2.0 cm, n = 72). Results: Cases of high %ASF tumors showed significantly lower frequencies of lymphovascular invasion (p = 0.008). Immunohistochemical staining revealed that the expression score of laminin-5, invasive-related molecule, in cancer cells was significantly lower in high %ASF cases than in low %ASF cases (p = 0.001). Within the same tumor, laminin-5 expression in the ASF area was significantly lower than that in the ASD area (p = 0.001). The overall 5-year survival rate of patients with a larger ASD area (> 1.0 cm2) was significantly lower than that of patients with a smaller ASD area (≤ 1.0 cm2) (p = 0.017). Conclusions: In this study, we clearly showed that cancer cells presenting with ASF represents a "less invasive phenotype" in peripheral SCC.
- Subjects
SQUAMOUS cell carcinoma; LUNGS; CANCER cells; IMMUNOSTAINING; DIGITAL images
- Publication
Journal of Cancer Research & Clinical Oncology, 2019, Vol 145, Issue 7, p1773
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-019-02937-9