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- Title
Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies.
- Authors
Franko, R.; Franko, Y.; Ribes Martinez, E.; Ferronato, G. A.; Heinzelmann, I.; Grechi, N.; Devkota, S.; Fontes, P. K.; Coeti, R.; Oshiro, T. S. I.; Ferraz, M. A. M. M.
- Abstract
Understanding the mechanical properties and porosity of reproductive tissues is vital for regenerative medicine and tissue engineering. This study investigated the changes in Young's modulus (YM), storage modulus (E′), loss modulus (Eʺ), and porosity of native and decellularized bovine reproductive tissues during the estrous cycle. Testis tunica albuginea had significantly higher YM, E′, and Eʺ than the inner testis, indicating greater stiffness and viscoelasticity. Endometrium showed no distinct differences in YM, E′, or Eʺ across the estrous cycle or between horns. Ovaries exhibited significant variations in YM, E′, Eʺ, and porosity, with higher YM and E′ in the ipsilateral cortex and medulla during the luteal phase. Decellularized ovarian tissues displayed increased porosity. The oviduct displayed no significant differences in YM or E′ in the isthmus, but the contralateral ampulla had reduced YM and E′ in the luteal phase. These findings offer valuable insights into the dynamic mechanical properties and porosity of reproductive tissues, facilitating the development of biomimetic scaffolds for tissue engineering applications.
- Subjects
TISSUE engineering; ENDOMETRIUM; ESTRUS; LUTEAL phase; YOUNG'S modulus; BIOMIMETIC materials
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-57867-5