We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Copper‐Catalyzed Oxidative [1+2+1+2] Cascade Cyclization of N,N‐Dimethyl Enaminones with Benzylamines: A Facile Access to Functionalized 1,4‐Dihydropyridines.
- Authors
Sun, Yulin; Chai, Zhangmengjie; Liu, Donghan; Zhang, Mingshuai; Chen, Longkun; Liu, Zhuoyuan; Wang, Yongchao; Yu, Fuchao
- Abstract
Using benzylamines as the C4 source of 1,4‐dihydropyridines (1,4‐DHPs), a Cu‐catalyzed oxidative [1+2+1+2] cascade cyclization for the synthesis of 1,4‐DHPs was firstly developed. A broad range of easily available N,N‐dimethyl enaminones and benzylamines are employed smoothly to provide a diverse range of 1,4‐DHPs with high efficiency. This method is performed by a one‐pot cascade C(sp3)−H bond functionalization/C(sp3)−N cleavage/cyclization strategy to form simultaneously two C(sp3)−C(sp2) bonds, two C(sp2)−N bonds, and a 1,4‐DHP ring.
- Subjects
BENZYLAMINES; RING formation (Chemistry); DIHYDROPYRIDINE; COPPER
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 28, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202300297