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- Title
Protein homeostasis: live long, won't prosper.
- Authors
Toyama, Brandon H.; Hetzer, Martin W.
- Abstract
Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. An increasing number of intracellular proteins, however, have been identified that evade this turnover process and instead are maintained over a cell's lifetime. This diverse group of long-lived proteins might be particularly prone to accumulation of damage and thus have a crucial role in the functional deterioration of key regulatory processes during ageing.
- Subjects
PROTEINS; PROTEOMICS; POLYPEPTIDES; AGING; HOMEOSTASIS
- Publication
Nature Reviews Molecular Cell Biology, 2013, Vol 14, Issue 1, p55
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3496