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- Title
THE FREQUENCY OF VITAMIN B<sub>12</sub> DEFICIENCY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH METFORMIN FOR AT LEAST FIVE YEARS.
- Authors
CRĂCIUN, ELENA CRISTINA; LEUCUŢA, DANIEL CORNELIU; ŢĂRMURE, SIMINA FELICIA; COPCEA, ILINCA; COPCEA, ADRIAN; UNGUR, RODICA ANA; PARA, IOANA
- Abstract
This study was carried out in order to determine the frequency of vitamin B12 deficiency in Romanian patients with type 2 diabetes mellitus (T2DM), treated with metformin for at least five years. The study group included 39 T2DM patients and 33 control subjects. A complete blood count was performed and serum vitamin B12 concentration was determined. The T2DM patients on metformin had statistically significant lower levels of B12 vitamin, adjusted for age and gender, and of haemoglobin compared to control subjects. Older patients, as well as male patients, had statistically significant lower B12 vitamin levels. No statistically significant association was found between the vitamin B12 level and the duration of metformin treatment. These results suggest the importance of assessing vitamin B12 status in T2DM patients treated with metformin on long term.
- Subjects
TYPE 2 diabetes; VITAMIN deficiency; BLOOD cell count; METFORMIN; OLDER patients
- Publication
Farmacia, 2021, Vol 69, Issue 5, p872
- ISSN
0014-8237
- Publication type
Article
- DOI
10.31925/farmacia.2021.5.7