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- Title
TOXICITY INVESTIGATION OF AN EXTRACT OF AMARANTHUS RETROFLEXUS L. (AMARANTHACEAE) LEAVES.
- Authors
DINU, MIHAELA; ANGHEL, ADRIANA IULIANA; OLARU, OCTAVIAN TUDOREL; ȘEREMET, OANA CRISTINA; CALALB, TATIANA; COJOCARU-TOMA, MARIA; NEGREŞ, SIMONA; HOVANEŢ, MARILENA VIORICA; ZBÂRCEA, CRISTINA ELENA; ANCUCEANU, ROBERT
- Abstract
The dry hydro-ethanolic extract obtained from leaves of Amaranthus retroflexus L. (Amaranthaceae) with an yield of 22.53% was assessed with respect to its acute toxicity in NMRI mice, cytotoxicity on the crustacean Daphnia magna and phytotoxicity on Triticum aestivum L. The lack of lethality and of any change in the indicators followed in mice (2000 mg/kg b.w. po) was demonstrated, the extract being classified into the 5th category of the Global Harmonized System (GHS). The Daphnia magna test results indicated a low toxicity (LC50 of 1053.0 μg/mL), in agreement with the results above, and the cytotoxicity and genotoxicity on plant cell, investigated by the Triticum bioassay manifest at high concentrations only (1.00% - 0.100%), for which changes in the mitotic film are also observed: mitoinhibition, anaphases with retarded chromosomes, metaphases with "sticky" chromosomes.
- Subjects
AMARANTHACEAE; PLANT extracts; EFFECT of poisons on plants; CELL-mediated cytotoxicity; DAPHNIA magna
- Publication
Farmacia, 2017, Vol 65, Issue 2, p289
- ISSN
0014-8237
- Publication type
Article