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- Title
Adherence to Aromatase Inhibitors among Postmenopausal Breast Cancer Patients in Middle Euphrates Region of Iraq.
- Authors
Mjali, Ahmed; Oudah, Alyaa Hadi; Al-Shammari, Haider Hasan Jaleel; Abbas, Nareen Tawfeeq
- Abstract
Background: Aromatase inhibitors AIs, are now widely used hormonal therapy in postmenopausal breast cancer patients with hormone receptors positive because of their clinical effectiveness in both adjuvant and metastatic setting. Adherence to therapy and compliance with professional instructions are critical in the management since poor compliance to treatment leading to inferior outcomes. Aims: To determine the adherence of patients to AIs therapy and factors associated with non-adherence among breast cancer patients in Middle Euphrates region of Iraq. Methods: This study was conducted in Al-Hussein cancer center in Karbala province of Iraq, between January 2020 and December 2020. There were 101 breast cancer patients treated with AIs, their adherence was assessed by using the validated Morisky Medication Adherence Scale (8-MMAS). Results: Majority of patients had a high adherence in (62.38%) while (37.62%) of our patients were suboptimal adherence. Forgetfulness was the main cause of poor adherence in (71.05%) of patients. Bone and joint pain were the most frequent side effect among our patients. There was no significant association between age, educational level, marital status, income, parity, prior treatment and adherence (p-vale > 0.05). Conclusion: These data suggest that more than one third of the patients have suboptimal adherence to Aromatase inhibitors. The factors associated with poor adherence were unintentional (forgetfulness), but also included intentional factors, such as drug inconvenience and avoidance of adverse effects. Paying attention to the factors found in this study might help to improve outcomes among breast cancer patients.
- Subjects
IRAQ; KARBALA (Iraq); HORMONE receptor positive breast cancer; AROMATASE inhibitors; CANCER patients; PATIENT compliance; BREAST cancer
- Publication
Kerbala Jorunal of Medicine, 2021, Vol 14, Issue 1, p2419
- ISSN
1990-5483
- Publication type
Article