We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Postoperative Radiotherapy for Resected Pathological Stage IIIA-N2 Non-Small Cell Lung Cancer: A Retrospective Study of 221 Cases from a Single Institution.
- Authors
Honghai Dai; Zhouguang Hui; Wei Ji; Jun Liang; Jima Lu; Guangfei Ou; Zongmei Zhou; Qinfu Feng; Zefen Xiao; Dongfu Chen; Hongxing Zhang; Weibo Yin; Jie He; Luhua Wang
- Abstract
Background. For patients with resected pathological stage IIIA-N2 non-small cell lung cancer (NSCLC), the role of postoperative radiotherapy (PORT) is not well defined. In this single-institutional study, we re-evaluated the effect of PORT on overall survival (OS) as well as tumor control in this subgroup of patients. Methods. In 2003-2005, 221 consecutive patients with resected pathological stage IIIA-N2 NSCLC at our institution were retrospectively analyzed in an institutional review board-approved study. The effect of PORT on OS, cancer-specific survival (CSS), and disease-free survival (DFS) was evaluated using the Kaplan-Meier method and log-rank tests. The impact of PORT on locoregional control and distant metastasis was also analyzed. Results. Compared with the control, patients treated with PORT had a significantly longer OS time (X2, 3.966; p = .046) and DFS interval (X2, 6.891; p = .009), as well as a trend toward a longer CSS duration (X2, 3.486; p = .062). Patients treated with PORT also had a significantly higher locoregional recurrence-free survival rate (X2, 5.048; p = .025) as well as distant metastasis-free survival rate (X2, 11.248; p = .001). Multivariate analyses showed that PORT was significantly associated with a longer OS duration (p = .000). Conclusions. PORT can significantly improve the survival of patients with resected pathological stage IIIA-N2 NSCLC. A prospective randomized multicenter clinical trial is ongoing.
- Subjects
CHI-squared test; COMPUTER software; LUNG cancer; MULTIVARIATE analysis; POSTOPERATIVE period; PROGNOSIS; SURVIVAL analysis (Biometry); TUMOR classification; DATA analysis; CONTINUING education units; RETROSPECTIVE studies
- Publication
Oncologist, 2011, Vol 16, Issue 5, p641
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2010-0343