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- Title
Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila.
- Authors
Kuo, Ying; Huang, Huanwei; Cai, Tao; Wang, Tao
- Abstract
Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine protein kinase that functions as a central regulator of cellular growth and metabolism by forming two distinct complexes: TOR complex 1 (TORC1) and TORC2. As well as TORC1, TORC2 plays a key role in regulation of cell growth. But little is known about how TORC2 regulates cell growth. The transcription factor Myc also plays a critical role in cell proliferation and growth. Here we report that TORC2 and Myc regulate cell growth via a common pathway. Expression of Myc fully rescued growth defects associated with lst8 and rictor mutations, both of which encode essential components of TORC2. Furthermore, loss of TORC2 disrupted the nuclear localization of Myc, and inhibited Myc-dependent transcription. Together, our results reveal a Myc-dependent pathway by which TORC2 regulates cell growth.
- Subjects
TOR proteins; SERINE/THREONINE kinases; REGULATION of cell growth; MYC proteins; TRANSCRIPTION factors; CELL proliferation
- Publication
Scientific Reports, 2015, p10339
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep10339