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- Title
Epilepsia partialis continua in type 1 diabetes: evolution into epileptic encephalopathy with continuous spike-waves during slow sleep.
- Authors
Baglietto, Maria Giuseppina; Mancardi, Maria Margherita; Giannattasio, Alessandro; Minuto, Nicola; Rossi, Andrea; Capovilla, Giuseppe; Veneselli, Edvige; Lorini, Renata; d'Annunzio, Giuseppe
- Abstract
Hyperglycemic status may be rarely complicated by Epilepsia partialis continua (EPC) that usually responds to metabolic normalization. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) play a pivotal role in the autoimmune process that leads to clinical onset of type 1 diabetes mellitus (T1DM). GAD-Ab have been recently reported in association with rare forms of refractory epilepsy, with or without association to T1DM. Here we describe a young patient who developed EPC five months after T1DM onset; GAD-Ab were detected in his cerebrospinal fluid with evidence of oligoclonal bands. His epileptic disorder evolved over time into drug-resistant epilepsy with continuous spike-waves during slow sleep and severe behavioral impairment. The role of both metabolic imbalance and GAD autoimmunity is discussed.
- Subjects
EPILEPSY; DIABETES; HEPATIC encephalopathy; AUTOIMMUNITY; NEUROSCIENCES
- Publication
Neurological Sciences, 2009, Vol 30, Issue 6, p509
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-009-0122-y