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- Title
Expression and function of human steroid receptor RNA activator in prostate cancer cells: role of endogenous hSRA protein in androgen receptor-mediated transcription.
- Authors
Kurisu, T.; Tanaka, T.; Ishii, J.; Matsumura, K.; Sugimura, K.; Nakatani, T.; Kawashima, H.
- Abstract
Steroid receptor RNA activator (SRA) was first isolated as a steroid receptor co-activator that functioned as an RNA transcript. Later, we demonstrated that SRA needs to be translated in order to co-activate androgen receptor (AR). Here, we showed that three isoforms of human SRA enhanced AR activities. Small interfering RNA against SRA suppressed AR activities in PC-3 cells transfected with pSG5AR and in LNCaP cells that have an endogenous mutated-AR. Western blot showed that SRA protein was expressed at a higher level in PC-3 than in LNCaP cells, suggesting that SRA may be related to hormone-independent growth of prostate cancer.Prostate Cancer and Prostatic Diseases (2006) 9, 173–178. doi:10.1038/sj.pcan.4500867; published online 11 April 2006
- Subjects
PROSTATE cancer; SMALL interfering RNA; ANTISENSE RNA; TUMOR growth; CANCER
- Publication
Prostate Cancer & Prostatic Diseases, 2006, Vol 9, Issue 2, p173
- ISSN
1365-7852
- Publication type
Article
- DOI
10.1038/sj.pcan.4500867