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- Title
The Road Less Traveled: Should We Omit Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer?
- Authors
Sio, Terence T.; Prayongrat, Anussara; Yun Zhang; Qin Lin; Ting Xu; Zhongxing Liao; Jinbo Yue; Zhang, Yun; Lin, Qin; Xu, Ting; Liao, Zhongxing; Yue, Jinbo
- Abstract
New randomized data from Japan have raised questions regarding the use of prophylactic cranial irradiation for patients with extensive-stage small-cell lung cancer but without detectable brain metastases on magnetic resonance imaging. In the present focused review, we examine the general role of prophylactic cranial irradiation in the management of small-cell lung cancer and present relevant controversies from both sides of the discussion. Future directions for clinical investigation and research are also highlighted. Strategies for neurocognitive protection, including memantine use and hippocampal sparing using modulated radiotherapy techniques, are also presented.
- Subjects
BRAIN tumors; COMPARATIVE studies; LUNG cancer; LUNG tumors; RESEARCH methodology; MEDICAL cooperation; RADIOTHERAPY; RESEARCH; EVALUATION research
- Publication
Clinical Lung Cancer, 2018, Vol 19, Issue 4, p289
- ISSN
1525-7304
- Publication type
journal article
- DOI
10.1016/j.cllc.2018.03.006