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- Title
Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study.
- Authors
DAISUKE ASAOKA; TSUTOMU TAKEDA; YOSHIHIRO INAMI; DAIKI ABE; YUJI SHIMADA; KENSHI MATSUMOTO; HIROYA UEYAMA; KOHEI MATSUMOTO; HIROYUKI KOMORI; YOICHI AKAZAWA; TARO OSADA; MARIKO HOJO; AKIHITO NAGAHARA
- Abstract
The aim of the present study was to investigate the association between the severity of constipation and sarcopenia in elderly adults. We conducted a single‑center university hospital‑based, retrospective cross‑sectional study of consecu‑ tive outpatients aged ≥65 years from 2017 to 2020. Patients were included in the study if all of the following information were available from medical records: Patient's profile (age, sex, body mass index), laxative/prokinetics use, evaluation of sarcopenia, nutritional status, and questionnaires concerning the severity of constipation [Constipation Scoring System (CSS)], abdominal symptom‑related quality of life (QOL) (Izumo scale) and stool shape [Bristol Stool Form Scale (BSFS)]. Multiple regression analysis of risk factors for high CSS score was performed. The results revealed that of the 310 eligible study subjects, [149 men (48.1%) and 161 women (51.9%); mean age, 75.7±6.1 years; mean body mass index, 23.0±3.6 kg/m²], sarcopenia was noted in 83 cases (26.8%). The CSS score was significantly higher in the sarcopenia group than that noted in the non‑sarcopenia group (4.9±4.9 vs. 3.6±3.6, P=0.009). The CSS score was significantly associated with the albumin level (r=‑0.148), lymphocyte count (r=‑0.118), CONUT score (r=0.130), reflux‑related QOL score (r=0.155), upper abdominal pain‑related QOL score (r=0.171), fullness‑related QOL score (r=0.299), constipation‑related QOL score (r=0.615), diarrhea‑related QOL score (r=0.235) and BSFS score (r=‑0.114). In multiple regression analysis, indepen‑ dent predictors for CSS score were sarcopenia [standardized partial regression coefficient (β)=0.107, P=0.032], constipa‑ tion‑related QOL score (β=0.537, P<0.001), laxative/prokinetics use (β=0.211, P<0.001) and BSFS score (β=‑0.098, P=0.031) (R²=0.436). In conclusion, sarcopenia, constipation‑related QOL score, laxative/prokinetics use and BSFS score are associ‑ ated with the severity of constipation in elderly adults.
- Subjects
SARCOPENIA; CONSTIPATION; OLDER people; MULTIPLE regression analysis; QUALITY of life
- Publication
Biomedical Reports, 2021, Vol 14, Issue 1, p1
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2020.1378