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- Title
How Reversed-Phase Liquid Chromatography Works.
- Authors
Schure, Mark R.; Rafferty, Jake L.; Zhang, Ling; Siepmann, J. ilja
- Abstract
The keys to understanding reversed-phase liquid chromatography (LC) are provided at the molecular mechanism level as determined by high accuracy molecular simulation. The essential features of C18 stationary-phase chains in contact with methanol-water and acetonitrile-water mixtures are discussed in the context of bonded-chain geometry, spatial distribution of alkane and alcohol solutes, retention mechanism, and retention thermodynamics. This tutorial is intended to be applicable to a wide audience ranging from occasional users of liquid chromatography to separation scientists.
- Subjects
LIQUID chromatography; CHROMATOGRAPHIC analysis; CHIRAL stationary phases; HYDROPHOBIC compounds; SURFACE chemistry; SOLVENT analysis
- Publication
LC-GC Europe, 2014, Vol 27, Issue 1, p18
- ISSN
1471-6577
- Publication type
Article