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- Title
ALK‐rearranged CD30‐positive poorly differentiated lung adenocarcinoma, mimicking anaplastic large‐cell lymphoma.
- Authors
George, Giby V; Wallace, Danielle S; Wang, Ying; Carney, John; Elsadawi, Murad; Burack, W Richard; Evans, Andrew G; Barr, Paul M; Velez, Moises J; El Hussein, Siba
- Abstract
This article discusses a case of a 64-year-old man who presented with back pain and cough. Imaging revealed masses in the chest and abdomen, as well as pleural effusions. Pathological examination of the tissue revealed a poorly differentiated malignant neoplasm that initially appeared to be anaplastic large-cell lymphoma (ALCL) based on immunohistochemical staining. However, further molecular testing confirmed a diagnosis of ALK-rearranged lung adenocarcinoma. The patient has responded to ALK-inhibitor therapy. The article emphasizes the importance of careful interpretation of immunohistochemical stains in cases of poorly differentiated ALK+/CD30+ neoplasms.
- Subjects
ANAPLASTIC large-cell lymphoma; CAUDA equina syndrome
- Publication
Histopathology, 2024, Vol 84, Issue 5, p900
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.15105