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- Title
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products.
- Authors
Hou, Song-Yu; Yan, Bing-Chao; Sun, Han-Dong; Puno, Pema-Tenzin
- Abstract
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural frameworks. The [2 + 2] cycloaddition is unequivocally the primary and most commonly used method for synthesizing cyclobutanes. In this review, we have summarized the application of the [2 + 2] cycloaddition with different reaction mechanisms in the chemical synthesis of selected cyclobutane-containing natural products over the past decade.
- Subjects
CHEMICAL synthesis; NATURAL products; CHEMICAL reactions; CYCLOBUTANE; RING formation (Chemistry)
- Publication
Natural Products & Bioprospecting, 2024, Vol 14, Issue 1, p1
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-024-00457-9