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- Title
Effect of Radix Ilicis Pubescentis on the Rats with Hyperlipidemia.
- Authors
Chaoyan QIN; Jiangcun WEI; Peitao XIE; Wen ZHONG; Shengbin CHEN; Fengxian ZHAO; Qian HAN
- Abstract
[Objectives] To study the hypolipidemic effect of Radix Ilicis Pubescentis and to provide experimental scientific basis for the study of hypolipidemic mechanism of Radix Ilicis Pubescentis. [Methods] 60 healthy(SD) male rats were selected, 10 rats were given basic feed and pure water as blank control group, and the other 50 rats were fed with high-fat diet for 4 weeks. After establishing the hyperlipidemic rat model, the rats were randomly divided into model group, high, middle and low dose groups(1 000, 800, 500 mg/kg), and positive control group(simvastatin 0.4 mg/mL). The corresponding drugs were intragastrically administered to the rats in each group(blank control group and model group intragastrically administered with normal saline). Four weeks later, blood samples from abdominal aorta were taken to detect serum total cholesterol(TC), serum triglyceride(TG), low density lipoprotein cholesterol(LDL-C), and high density lipoprotein cholesterol(HDL-C). [Results] Compared with the blank control group, TC, TG and LDL-C increased while HDL-C decreased in the model group(P<0.05); compared with the model group, TC, TG and LDL-C in Radix Ilicis Pubescentis group decreased to varying degrees, and the content of HDL-C in serum of rats had no statistical significance. Compared with the blank control group, the serum TC and TG contents of the model group, positive control group, high, middle and low dose groups of Radix Ilicis Pubescentis extract significantly increased(P<0.01 or 0.05), and the serum LDL-C content of rats decreased(P<0.05). [Conclusions] The extract of Radix Ilicis Pubescentis had a certain lipid-lowering effect on hyperlipidemia in rats, and had obvious preventive and therapeutic effect on hyperlipidemia.
- Subjects
HYPERLIPIDEMIA; RATS; BLOOD cholesterol; ABDOMINAL aorta; TREATMENT effectiveness; LOW density lipoproteins
- Publication
Medicinal Plant, 2020, Vol 11, Issue 4, p78
- ISSN
2152-3924
- Publication type
Article
- DOI
10.19600/j.cnki.issn2152-3924.2020.04.019