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- Title
Preventive Effects of Vitamin C And Polysaccharides in Dioscrea pposite Thunb. on Cadmium-induced Liver Injury in Mice.
- Authors
ZHANG, Hongmei; SUN, Shezong; GUAN, Shoutao; ZHAO, Jie
- Abstract
[Objective] To investigate the preventive protective effects and its mechanism of vitamin C and polysaccharide in Dioscrea pposite Thunb. on cadmium-induced liver damage in mice. [Methods] 50 Kunming mice were randomly divided into control group, model group, D. pposite polysaccharides protection group, vitamin C protection group, D. pposite polysaccharides and vitamin C protection group. At the 7 day of feeding, the mice were given saline by gavage, and the mice in other groups were intraperitoneally injected with 3. 0 mg/kg CdCl2 solution. 24 hours after injection, blood was collected for ALT and AST test. Then, mice were sacrificed and the livers were removed for the calculation of hepatosomatic index (liver weight / body weight). Also, the liver homogenates were prepared for the determination of SOD and GSH-Px activities and the of MDA and NO contents. [Results] Compared with the mice in model group, the liver-somatic index, serum ALT, AST activity, and contents of liver MDA and NO reduced, the activities of SOD and GSH-Px, and the content of GSH improved in D. pposite polysaccharides and vitamin C protection group (P <0. 05, P <0. 01).compared with the model grfoup, the protective effects of D. pposite polysaccharides combined with vitamin C strengthened (P<0.01). [Conclusions] The combination of D. pposite polysaccharides and vitamin C has preventive protection effects on cadmium-induced liver injury in mice by antagonizing cadmium and/or oxidative stress. The application of D. pposite polysaccharides combined with vitamin C had a synergistic effect.
- Subjects
GLYCANS; BIOPOLYMERS; POLYSACCHARIDES; TRANSITION metals; ASCORBIGENS
- Publication
Medicinal Plant, 2014, Vol 5, Issue 6, p36
- ISSN
2152-3924
- Publication type
Article