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- Title
Physiochemical disparity of mismatched HLA class I alloantigens and risk of acute GVHD following HSCT.
- Authors
Kosmoliaptsis, V; Jöris, M M; Mallon, D H; Lankester, A C; von dem Borne, P A; Kuball, J; Bierings, M; Cornelissen, J J; Groenendijk-Sijnke, M E; van der Holt, B; Bradley, J A; Oudshoorn, M; van Rood, J J; Taylor, C J; Claas, F H J
- Abstract
We determined whether assessment of the immunogenicity of individual donor-recipient HLA mismatches based on differences in their amino-acid sequence and physiochemical properties predicts clinical outcome following haematopoietic SCT (HSCT). We examined patients transplanted with 9/10 single HLA class I-mismatched grafts (n=171) and 10/10 HLA-A-, -B-, -C-, -DRB1- and -DQB1-matched grafts (n=168). A computer algorithm was used to determine the physiochemical disparity (electrostatic mismatch score (EMS) and hydrophobic mismatch score (HMS)) of mismatched HLA class I specificities in the graft-versus-host direction. Patients transplanted with HLA-mismatched grafts with high EMS/HMS had increased incidence of ⩾grade II acute GVHD (aGVHD) compared with patients transplanted with low EMS/HMS grafts; patients transplanted with low and medium EMS/HMS grafts had similar incidence of aGVHD to patients transplanted with 10/10 HLA-matched grafts. Mortality was higher following single HLA-mismatched HSCT but was not correlated with HLA physiochemical disparity. Assessment of donor-recipient HLA incompatibility based on physiochemical HLA disparity may enable better selection of HLA-mismatched donors in HSCT.
- Subjects
STEM cell transplantation; CELL transplantation; HLA histocompatibility antigens; TRANSPLANTATION of organs, tissues, etc.; GRAFT versus host disease; THERAPEUTICS
- Publication
Bone Marrow Transplantation, 2015, Vol 50, Issue 4, p540
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2014.305