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- Title
A fludarabine, thiotepa reduced toxicity conditioning regimen designed specifically for allogeneic second haematopoietic cell transplantation after failure of previous autologous or allogeneic transplantation.
- Authors
Grüllich, C.; Bertz, H.; Spyridonidis, A.; Müller, C. I.; Finke, J.
- Abstract
We present a phase II study of fludarabine 5 × 30 mg/m2, thiotepa 3 × 5 mg/kg as preparative regimen specifically for allogeneic second haematopoietic stem cell transplantation (HCT) after failure of previous HCT. Forty-nine patients (median age 52 years, range 27–68) received an allogeneic second HCT after failed autologous (n=29) or allogeneic (n=20) HCT. Diagnoses were AML (n=18), ALL (n=3), multiple myeloma (n=11), lymphoma (n=16) and CML (n=1). GVHD prophylaxis consisted of CYA and mainly low dose alemtuzumab (40 mg). The median follow-up for patients alive is 528 days (range 217–1344). In 43 of 49 (88%) evaluable patients response rates were CR=19, PR=14 and SD=10 at one month. At one year, the probability (95% confidence interval) of relapse is 55.1 (38.2–72)% and the nonrelapse mortality (NRM) is 29 (14.2–44.4)%. Estimated survival at one year is 42.6 (28.7–56.6)% and event free survival is 38.1 (24.4–51.8)%. Survival was significantly better for patients experiencing relapse beyond one year, than for patients relapsing within one year from first transplantation (51.2 (33.5–68.9)% vs 27 (7–48.5)%; P=0.013). We conclude that this regimen is feasible and well tolerated for allogeneic second HCT.Bone Marrow Transplantation (2008) 41, 845–850; doi:10.1038/sj.bmt.1705989; published online 21 January 2008
- Subjects
HEMATOPOIETIC stem cells; STEM cell transplantation; FLUDARABINE; ANTINEOPLASTIC agents; DRUG therapy; MULTIPLE myeloma; DIAGNOSIS
- Publication
Bone Marrow Transplantation, 2008, Vol 41, Issue 10, p845
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705989