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- Title
Genome-wide association study of bipolar I disorder in the Han Chinese population.
- Authors
Lee, M. T. M.; Chen, C. H.; Lee, C. S.; Chen, C. C.; Chong, M. Y.; Ouyang, W. C.; Chiu, N. Y.; Chuo, L. J.; Chen, C. Y.; Tan, H. K. L.; Lane, H. Y.; Chang, T. J.; Lin, C. H.; Jou, S. H.; Hou, Y. M.; Feng, J.; Lai, T. J.; Tung, C. L.; Chen, T. J.; Chang, C. J.
- Abstract
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10−7 (rs2709736) and 6.05 × 10−6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10−6) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10−5), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10−5 and P=1.48 × 10−5, respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.
- Subjects
CHINA; BIPOLAR disorder; GENETIC polymorphisms; CAUCASIAN race; POTASSIUM channels; CALCIUM channels; ETHNOLOGY
- Publication
Molecular Psychiatry, 2011, Vol 16, Issue 5, p548
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/mp.2010.43