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- Title
What is the effect of adjusting for more than one measure of current body size on the relation between birthweight and blood pressure?
- Authors
Tu, Y.-K; Gilthorpe, M. S.; Ellison, G. T. H.
- Abstract
The statistical validity of the negative associations observed between birthweight and disease in later life has recently been questioned, because these associations might be due, in part, to inappropriate adjustment for current body size, creating a statistical artefact known as the ‘reversal paradox’. The aim of this study was to explore the effect of adjusting for more than one measure of current body size on the association between birthweight and disease in later life using simulations and meta-analyses of empirical studies. The simulations examined the relation between birthweight and adult systolic blood pressure before and after adjusting for one, two or three measures of current body size by including current weight and subsequently adding body mass index and height in successive analytical models. Meta-analyses were then performed to compare the effect sizes observed among empirical studies reporting associations between birthweight and blood pressure before and after adjusting for one or two measures of current body size. The meta-analyses confirmed the results of the simulations – both showed that associations between birthweight and blood pressure tend to become increasingly negative following adjustment for current body size, and that this effect is enhanced after adjusting for additional measures of current body size.Journal of Human Hypertension (2006) 20, 646–657. doi:10.1038/sj.jhh.1002044; published online 11 May 2006
- Subjects
HYPERTENSION; LOW birth weight; BIRTH size; BODY size; BODY mass index; PHYSIOLOGY
- Publication
Journal of Human Hypertension, 2006, Vol 20, Issue 9, p646
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1002044