We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cystatin C relates to metabolism in healthy, pubertal adolescents.
- Authors
Ziegelasch, Niels; Vogel, Mandy; Körner, Antje; Koch, Eva; Jurkutat, Anne; Ceglarek, Uta; Dittrich, Katalin; Kiess, Wieland
- Abstract
Introduction: The cystatin C (CysC) serum level is a marker of glomerular filtration rate and depends on age, gender, and pubertal stage. We hypothesize that CysC might overall reflect energy homeostasis and be regulated by components of the endocrine system and metabolites in pubertal adolescents. Methods: Serum CysC levels and further possible effector parameters in 5355 fasting, morning venous blood samples from 2035 healthy participants of the LIFE Child cohort study (age 8 to 18 years) were analyzed. Recruitment started in 2011, with probands followed up once a year. Linear univariate and stepwise multivariate regression analyses were performed. Results: Annual growth rate, serum levels of thyroid hormones, parathyroid hormone, insulin-like growth factor 1, hemoglobin A1c (HbA1c), uric acid, and alkaline phosphatase show relevant and significant associations with CysC serum concentrations (p <0.001). Furthermore, male probands' CysC correlated with the body mass index and testosterone among other sexual hormones. Multivariate analyses revealed that uric acid and HbA1c are associated variables of CysC independent from gender (p <0.001). In males, alkaline phosphatase (p <0.001) is additionally significantly associated with CysC. Thyroid hormones show significant correlations only in multivariate analyses in females (p <0.001). Conclusions: The described associations strongly suggest an impact of children's metabolism on CysC serum levels. These alterations need to be considered in kidney diagnostics using CysC in adolescents. Additionally, further studies are needed on CysC in children.
- Subjects
ENDOCRINE system physiology; STATISTICS; PROTEINS; GAMMA-glutamyltransferase; ALBUMINS; STATURE; GLYCOSYLATED hemoglobin; ALKALINE phosphatase; CYSTATINS; HORMONES; SKINFOLD thickness; FOLLICLE-stimulating hormone; THYROID hormones; UREA; MULTIVARIATE analysis; TESTOSTERONE; AGE distribution; PUBERTY; BLOOD collection; REGRESSION analysis; BLOOD sugar; SEX distribution; PARATHYROID hormone; INSULIN; LUTEINIZING hormone; DATA analysis software; STATISTICAL sampling; URIC acid; BODY mass index; METABOLITES; ALANINE aminotransferase; ASPARTATE aminotransferase; BLOOD; ADOLESCENCE
- Publication
Pediatric Nephrology, 2022, Vol 37, Issue 2, p423
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-021-05209-2