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- Title
Filamentous Bacteriophage—A Powerful Carrier for Glioma Therapy.
- Authors
Wang, Yicun; Sheng, Jiyao; Chai, Jin; Zhu, Cuilin; Li, Xin; Yang, Wei; Cui, Ranji; Ge, Tongtong
- Abstract
Glioma is a life-threatening malignant tumor. Resistance to traditional treatments and tumor recurrence present major challenges in treating and managing this disease, consequently, new therapeutic strategies must be developed. Crossing the blood-brain barrier (BBB) is another challenge for most drug vectors and therapy medications. Filamentous bacteriophage can enter the brain across the BBB. Compared to traditional drug vectors, phage-based drugs offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents. This review summarized recent studies on phage-based glioma therapy and shed light on the developing therapeutics phage in the personalized treatment of glioma.
- Subjects
GLIOMAS; BACTERIOPHAGES; DISEASE relapse; BLOOD-brain barrier; DRUG therapy; BRAIN tumors
- Publication
Frontiers in Immunology, 2021, Vol 12, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2021.729336