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- Title
15–Lipoxygenase inhibition of Commelina benghalensis, Tradescantia fluminensis, Tradescantia zebrina.
- Authors
Alaba, Cean Socorro M.; Chichioco-Hernandez, Christine L.
- Abstract
Objective To evaluate the 15-lipoxygenase inhibitory activity of the methanol leaf extracts of Commelina benghalensis, Tradescantia fluminensis ( T. fluminensis ) and Tradescantia zebrina . Method The inhibitory activity was evaluated using a spectrophotometric assay by observing the increase in absorbance at 234 nm due to the formation of the product 13-hydroperoxyoctadecadienoic acid. The extracts were also tested for the presence of terpenoids, saponins, tannins, flavonoids, steroids, phenolic compounds, alkaloids and cardiac glycosides. Results All the extracts inhibited the action of 15-lipoxygenase at a concentration of 0.2 μg/mL. T. fluminensis and Tradescantia zebrina exhibited higher than 50% inhibition with T. fluminensis at 87.2%. T. fluminensis was partitioned with ethyl acetate and hexane and their IC 50 values were determined at 8.72 μg/mL and 98.04 μg/mL, respectively. Conclusions T. fluminensis is a potentially good source of 15-lipoxygenase inhibitors.
- Subjects
LIPOXYGENASES; DAYFLOWERS; SMALL-leaf spiderwort; ZEBRINA pendula; METHANOL; PLANT extracts; SPECTROPHOTOMETRY
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2014, Vol 4, Issue 3, p184
- ISSN
2221-1691
- Publication type
Article
- DOI
10.1016/S2221-1691(14)60229-X