We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
No association between in utero exposure to emissions from a coalmine fire and post-natal lung function.
- Authors
Hemstock, Emily J.; Foong, Rachel E.; Hall, Graham L.; Wheeler, Amanda J.; Dharmage, Shyamali C.; Dalton, Marita; Williamson, Grant J.; Gao, Caroline; Abramson, Michael J.; Johnston, Fay H.; Zosky, Graeme R.
- Abstract
Background and objective: Studies linking early life exposure to air pollution and subsequent impaired lung health have focused on chronic, low-level exposures in urban settings. We aimed to determine whether in utero exposure to an acute, high-intensity air pollution episode impaired lung function 7-years later. Method: We conducted a prospective cohort study of children who lived in the vicinity of a coalmine fire. Respiratory function was measured using the forced oscillation technique (FOT). Z-scores for resistance at 5 Hz (R5), reactance at 5 Hz (X5) and area under the reactance curve (AX) were calculated. Two sets of analyses were conducted to address two separate questions: (1) whether mine fire exposure (a binary indicator; conceived after the mine fire vs in utero exposed) was associated with the respiratory Z-scores; (2) whether there was any dose–response relationship between fire-related PM2.5 exposure and respiratory outcomes among those exposed. Results: Acceptable lung function measurements were obtained from 79 children; 25 unexposed and 54 exposed in utero. Median (interquartile range) for daily average and peak PM2.5 for the exposed children were 4.2 (2.6 – 14.2) and 88 (52—225) µg/m3 respectively. There were no detectable differences in Z-scores between unexposed and exposed children. There were no associations between respiratory Z-scores and in utero exposure to PM2.5 (daily average or peak). Conclusion: There was no detectable effect of in utero exposure to PM2.5 from a local coalmine fire on post-natal lung function 7-years later. However, statistical power was limited.
- Subjects
EMISSION exposure; ABANDONED children; FIRE exposure; LUNGS; AIR pollution
- Publication
BMC Pulmonary Medicine, 2023, Vol 23, Issue 1, p1
- ISSN
1471-2466
- Publication type
Article
- DOI
10.1186/s12890-023-02414-7