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- Title
Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration.
- Authors
Borroto-Escuela, Dasiel O.; Tarakanov, Alexander O.; Guidolin, Diego; Ciruela, Francisco; Agnati, Luigi F.; Fuxe, Kjell
- Abstract
It is proposed that the moonlighting concept can be applied to G protein coupled receptors (GPCRs) as, obviously, they can carry out different types of functions. The same motifs in, for example, the third intracellular loop, can moonlight by switching between receptor-receptor interactions and interactions with signaling proteins such as G proteins or calmodulin. A 'guide-and-clasp' manner of receptor-receptor interactions has been proposed where the 'adhesive guides' may be the triplet homologies. As an example, the triplets AAR (or RAA) and AAE (or EAA) homologies in A
- Subjects
NEURODEGENERATION; G proteins; PROTEIN-tyrosine kinases; HETEROMETRY; CELL receptors
- Publication
IUBMB Life, 2011, Vol 63, Issue 7, p463
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.473