We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Analysis of SNPs' Function in miR-21 and miR146a/b in Multiple Sclerosis and Active Lesions: An In Silico Study.
- Authors
Moraghebi, Mahta; Negahi, Ahmad Agha; Bazireh, Homa; Abbasi, Hossein; Ahmadi, Mohsen; Sarikhani, Zohreh; Mousavi, Pegah
- Abstract
Multiple sclerosis (MS) is a central nervous disorder caused by several factors. Studies have recently shown that non-coding RNA such as miRNA could participate in MS initiation, progression, and active lesion. This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. To fulfill this purpose, the SNPs were investigated for functionality through several online tools, including miRNA-SNP, SNP2-TFBS, RBP-Var, and RNAfold. Furthermore, SNPs of miR-21 and miR-146a/b that exist in pre-miRNA, mature miRNA, and promoter area were extracted; moreover, miRNA and RNA-binding protein interactions were analyzed. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions.
- Subjects
MICRORNA; MULTIPLE sclerosis; SINGLE nucleotide polymorphisms; NON-coding RNA; RNA-binding proteins; ALEMTUZUMAB
- Publication
Bioinformatics & Biology Insights, 2022, Vol 16, p1
- ISSN
1177-9322
- Publication type
Article
- DOI
10.1177/11779322221116322