We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Interaction of Host Cellular Proteins with Components of the Hepatitis Delta Virus.
- Authors
Greco-Stewart, Valerie; Pelchat, Martin
- Abstract
The hepatitis delta virus (HDV) is the smallest known RNA pathogen capable of propagation in the human host and causes substantial global morbidity and mortality. Due to its small size and limited protein coding capacity, HDV is exquisitely reliant upon host cellular proteins to facilitate its transcription and replication. Remarkably, HDV does not encode an RNA-dependent RNA polymerase which is traditionally required to catalyze RNA-templated RNA synthesis. Furthermore, HDV lacks enzymes responsible for post-transcriptional and -translational modification, processes which are integral to the HDV life cycle. This review summarizes the known HDV-interacting proteins and discusses their significance in HDV biology.
- Subjects
HEPATITIS D virus; HEPATITIS viruses; PATHOGENIC microorganisms; TRANSCRIPTION factors; RNA polymerases; HIV virus enzymes; RNA; MORTALITY; HUMAN life cycle
- Publication
Viruses (1999-4915), 2010, Vol 2, Issue 1, p189
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v2010189