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- Title
Potential Effects of Tocotrienols on Perimenopausal-associated Depression - A Mini Review.
- Authors
Liang, Gengfan; Kow, Audrey Siew Foong; Chau Ling Tham; Yu-Cheng Ho; Ming Tatt Lee
- Abstract
Perimenopausal depression is a type of emotional impairment that affects women between the ages of 56 and 66 before or after menopause. In addition to perimenopauserelated endocrine dysfunction, particularly hypogonadism and senescence, the chief symptoms of perimenopausal depression are emotional melancholy, anxiety and stress. Chemical antidepressant medications, such as tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAIOs), selective serotonin reuptake inhibitors (SSRIs), etc, and hormone replacement therapy are currently used to treat perimenopausal depression. However, these treatments only provide symptomatic relief to patients and have many side effects. While the development of conventional chemical antidepressant medicines for perimenopausal depression is generally slow, natural substances have recently emerged as research hotspots due to their potent therapeutic effects and relatively low risk of adverse effects. Tocotrienols, natural minor components form of vitamin E, are naturally present in many foods like wheat, rice bran oil, and palm oil, help treat perimenopausal depression in several ways, including by reducing oxidative stress damages and low-grade chronic inflammation. In this mini review, the potential antidepressant effects of tocotrienols are discussed from the perspectives of their anti-inflammatory, antioxidant and neurotransmitter regulatory abilities. Tocotrienols were investigated for their potential antidepressant properties utilising a variety of internet databases, including Pubmed and Google Scholar. To date, despite evidence from animal and in vitro studies indicating tocotrienols can reduce the severity of depressive symptoms by scavenging free radicals, reducing inflammation, and guarding against glutamate-induced neurotoxicity in cells, there has been no human clinical research to support this claim. Tocotrienols may be regarded as a potential antidepressant medication, however more clinical research is needed to confirm their impact and probable underlying mechanisms on perimenopausal depression.
- Subjects
ANTIDEPRESSANTS; SEROTONIN uptake inhibitors; RICE oil; MONOAMINE oxidase inhibitors; VITAMIN E; MENTAL depression; TRICYCLIC antidepressants
- Publication
Current Trends in Biotechnology & Pharmacy, 2023, Vol 17, p88
- ISSN
0973-8916
- Publication type
Article