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- Title
Small Choroidal Melanoma with Monosomy 3.
- Authors
Ghassemi, Fariba; Shields, Carol L.; Materin, Miguel A.; Shields, Jerry A.
- Abstract
Purpose: To report a patient with small juxtapapillary choroidal melanoma with chromosome 3 monosomy treated with I125 plaque and transpupillary thermotherapy (TTT). A 64-year-old Caucasian male presented with painless blurred vision of the left eye. Ocular examination disclosed a small juxtapapillary choroidal melanocytic tumor with overlying subretinal fluid and orange pigment. Ultrasound showed an elevated choroidal mass of 2 mm thickness with low reflectivity on A-scan and hollowness on B scan, consistent with a small choroidal melanoma. The patient was treated with plaque I125 radiotherapy combined with one session of TTT. Genetic testing of the tumor cells obtained by fine needle aspiration biopsy showed chromosome 3 monosomy. At 1 year after treatment, the tumor was regressed with resolution of subretinal fluid and 20/40 visual acuity. A small choroidal melanoma can manifest monosomy of chromosome 3, a known predictive factor for the development of systemic metastasis.
- Subjects
MELANOMA; PHOTOTHERAPY; VISUAL acuity; NEEDLE biopsy; MEDICAL imaging systems; RADIOTHERAPY; MEDICAL electronics; PATIENTS
- Publication
Middle East African Journal of Ophthalmology, 2010, Vol 17, Issue 3, p268
- ISSN
0974-9233
- Publication type
Article
- DOI
10.4103/0974-9233.65487