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- Title
Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C.
- Authors
Coppola, Nicola; Zampino, Rosa; Sagnelli, Caterina; Bellini, Giulia; Marrone, Aldo; Stanzione, Maria; Capoluongo, Nicolina; Boemio, Adriana; Minichini, Carmine; Adinolfi, Luigi Elio; Maione, Sabatino; Giudice, Emanuele Miraglia Del; Sagnelli, Evangelista; Rossi, Francesca
- Abstract
Background and Aim: To evaluate in anti-HCV-positive patients the clinical impact of the rs35761398 variant of the CNR2 gene leading to the substitution of Gln (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with Arg (R). Patients and Methods: 253 consecutive anti-HCV-/HCV-RNA-positive patients were enrolled, of whom 53 were HCV carriers with persistently normal ALT (PNALT group) and 200 had a history of steadily abnormal serum ALT values (abnormal ALT group). All patients were naive for antiviral therapy and were screened for the CNR2 rs35761398 polymorphism by a TaqMan assay. Results: Subjects in the PNALT group, compared with those in the abnormal ALT group were older (58.5±12 vs. 50.7±12.4 years, p = 0.001), more frequently female (66% vs. 42%, p = 0.003), with lower body massindex (BMI) (24.5±3.1 vs. 26.6±4.6, p = 0.003), and more frequently with HCV genotype 2 (43.1% vs 17.7%, p = 0.0002) and CB2-63 QQ variant (34% vs. 11%, p = 0.0001). Considering all 253 patients, no difference in the demographic, biochemical, or virological data was observed between patients in the different CB2-63 variants. The logistic regression analysis identified CB2-63 QQ, HCV genotype 2, older age and lower BMI as independent predictors of PNALT (p<0.00001). Discussion: The CB2-63 QQ variant in HCV patients was independently associated with the PNALT status.
- Subjects
HEPATITIS C treatment; CANNABINOID receptors; AMINOTRANSFERASES; SERUM; ANTIVIRAL agents; GENETIC polymorphisms
- Publication
PLoS ONE, 2014, Vol 9, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0099450