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Dimeric Amyloid Β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2004, v. 24, n. 15, p. 3801, doi. 10.1523/JNEUROSCI.5543-03.2004
By:
- Kawarabayashi, Takeshi;
- Shoji, Mikio;
- Younkin, Linda H.;
- Lin Wen-Lang;
- Dickson, Dennis W.;
- Murakami, Tetsuro;
- Matsubara, Etsuro;
- Abe, Koji;
- Ashe, Karen Hsiao;
- Younkin, Steven G.
Publication type:
Article
Association of Aβ42, Aβ40 and Aβ2/Aβ40 with cognitive impairment not demented (CIND) and dementia in persons of mexican ancestry (SALSA study): Different for diabetics versus non-diabetics?
Published in:
2010
By:
- Graff-Radford, Neill R.;
- Crook, Julia E.;
- Lucas, John A.;
- Younkin, Linda H.;
- Nah, Gregory;
- Younkin, Steven G.;
- Haan, Mary N.
Publication type:
Abstract
Association of a missense cathepsin D (CTSD) SNP with risk of Alzheimer's disease
Published in:
2009
By:
- Burgess, Jeremy;
- Leissring, Malcolm A.;
- Ma, Li;
- Younkin, Linda H.;
- Reinstatler, Lael;
- Crook, Julia E.;
- Pankratz, V. Shane;
- Dickson, Dennis W.;
- Peterson, Ronald C.;
- Graff-Radford, Neill R.;
- Younkin, Steven G.;
- Ertekin-Taner, Nilufer
Publication type:
Abstract
High plasma Aβ40 levels are associated with incident Cognitive Impairment not Demented (CIND) and dementia cases in persons of Mexican ancestry (SALSA study)
Published in:
2009
By:
- Graff-Radford, Neill R.;
- Crook, Julia E.;
- Lucas, John A.;
- Younkin, Linda H.;
- Moore, Kari A.B.;
- Younkin, Steven G.;
- Haan, Mary N.
Publication type:
Abstract
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
Published in:
2009
By:
- Carrasquillo, Minerva M.;
- Zou, Fanggeng;
- Pankratz, V. Shane;
- Wilcox, Samantha L.;
- Ma, Li;
- Walker, Louise P.;
- Younkin, Samuel G.;
- Younkin, Curtis S.;
- Younkin, Linda H.;
- Bisceglio, Gina D.;
- Ertekin-Taner, Nilufer;
- Crook, Julia E.;
- Dickson, Dennis W.;
- Petersen, Ronald C.;
- Graff-Radford, Neill R.;
- Younkin, Steven G.
Publication type:
Abstract
P1-370: Reduction of interference in sandwich ELISAs measuring the amyloid β protein in human plasma
Published in:
2008
By:
- Younkin, Linda H.;
- Brehm-Gibson, Tammy L.;
- Bisceglio, Gina D.;
- Graff-Radford, Neill R.;
- Younkin, Steven G.
Publication type:
Abstract
IC-P-087: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume
Published in:
2006
By:
- Graff-Radford, Neill R.;
- Weigand, Stephen D.;
- Shuing, Maria M.;
- Knopman, David S.;
- Boeve, Bradley F.;
- Lucas, John A.;
- Crook, Julia E.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Jack, Clifford R.;
- Younkin, Steven G.
Publication type:
Abstract
P3-102: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume
Published in:
2006
By:
- Graff-Radford, Neill R.;
- Weigand, Stephen D.;
- Shuing, Maria M.;
- Knopman, David S.;
- Boeve, Bradley F.;
- Lucas, John A.;
- Crook, Julia E.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Jack, Clifford R.;
- Younkin, Steven G.
Publication type:
Abstract
P1-310: Late onset Alzheimer’s disease (LOAD) susceptibility alleles in the insulin-degrading-enzyme gene (IDE) and other Aβ-degrading enzymes
Published in:
2006
By:
- Carrasquillo, Minerva M.;
- Younkin, Samuel G.;
- Kashino, Mariah R.;
- Wilcox, Samantha L.;
- Dincman, Toros A.;
- Howard, Melissa E.;
- Li, Ma;
- Zou, Fanggeng;
- Ertekin-Taner, Nilüfer;
- Allen, Mariet;
- Stanton, Chloë M.;
- Watson, Christopher M.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Graff-Radford, Neill;
- Younkin, Steven G.
Publication type:
Abstract
P1-308: Association of variants in Aβ processing genes with late onset Alzheimer’s disease (LOAD)
Published in:
2006
By:
- Younkin, Linda H.;
- Dincman, Toros;
- Lok, Johann;
- Raam, Manu;
- Zou, Fanggeng;
- Carrasquillo, Minerva;
- Ma, Li;
- Budjak, Ron;
- Younkin, Samuel;
- Petersen, Ronald;
- Graff-Radford, Neill;
- Younkin, Steven
Publication type:
Abstract
IC-P-087: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume
Published in:
2006
By:
- Graff-Radford, Neill R.;
- Weigand, Stephen D.;
- Shuing, Maria M.;
- Knopman, David S.;
- Boeve, Bradley F.;
- Lucas, John A.;
- Crook, Julia E.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Jack, Clifford R.;
- Younkin, Steven G.
Publication type:
Abstract
P3-102: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume
Published in:
2006
By:
- Graff-Radford, Neill R.;
- Weigand, Stephen D.;
- Shuing, Maria M.;
- Knopman, David S.;
- Boeve, Bradley F.;
- Lucas, John A.;
- Crook, Julia E.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Jack, Clifford R.;
- Younkin, Steven G.
Publication type:
Abstract
P1-310: Late onset Alzheimer’s disease (LOAD) susceptibility alleles in the insulin-degrading-enzyme gene (IDE) and other Aβ-degrading enzymes
Published in:
2006
By:
- Carrasquillo, Minerva M.;
- Younkin, Samuel G.;
- Kashino, Mariah R.;
- Wilcox, Samantha L.;
- Dincman, Toros A.;
- Howard, Melissa E.;
- Li, Ma;
- Zou, Fanggeng;
- Ertekin-Taner, Nilüfer;
- Allen, Mariet;
- Stanton, Chloë M.;
- Watson, Christopher M.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Graff-Radford, Neill;
- Younkin, Steven G.
Publication type:
Abstract
P1-308: Association of variants in Aβ processing genes with late onset Alzheimer’s disease (LOAD)
Published in:
2006
By:
- Younkin, Linda H.;
- Dincman, Toros;
- Lok, Johann;
- Raam, Manu;
- Zou, Fanggeng;
- Carrasquillo, Minerva;
- Ma, Li;
- Budjak, Ron;
- Younkin, Samuel;
- Petersen, Ronald;
- Graff-Radford, Neill;
- Younkin, Steven
Publication type:
Abstract
Environmental enrichment mitigates cognitive deficits in APP/PS1 transgenic mice
Published in:
2005
By:
- Jankowsky, Joanna L.;
- Melnikova, Tatiana;
- Fadale, Daniel J.;
- Xu, Guilian M.;
- Slunt, Hilda H.;
- Gonzales, Victoria;
- Younkin, Linda H.;
- Younkin, Steven G.;
- Borchelt, David R.;
- Savonenko, Alena V.
Publication type:
Abstract
Plasma AB levels as a premorbid biomarker for cognitive decline, mild cognitive impairment (MCI) and Alzheimer disease (AD)
Published in:
2005
By:
- Graff-Radford, Neill R.;
- Lucas, John A.;
- Crook, Julia E.;
- Boeve, Bradley F.;
- Knopman, David S.;
- Ivnik, Robert J.;
- Younkin, Linda H.;
- Petersen, Ronald C.;
- Younkin, Steven G.
Publication type:
Abstract
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
Published in:
Nature Genetics, 2009, v. 41, n. 2, p. 192, doi. 10.1038/ng.305
By:
- Carrasquillo, Minerva M.;
- Fanggeng Zou;
- Pankratz, V. Shane;
- Wilcox, Samantha L.;
- Li Ma;
- Walker, Louise P.;
- Younkin, Samuel G.;
- Younkin, Curtis S.;
- Younkin, Linda H.;
- Bisceglio, Gina D.;
- Ertekin-Taner, Nilufer;
- Crook, Julia E.;
- Dickson, Dennis W.;
- Petersen, Ronald C.;
- Graff-Radford, Neill R.;
- Younkin, Steven G.
Publication type:
Article
Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's Disease.
Published in:
PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008764
By:
- Carrasquillo, Minerva M.;
- Belbin, Olivia;
- Fanggeng Zou;
- Allen, Mariet;
- Ertekin-Taner, Nilufer;
- Ansari, Morad;
- Wilcox, Samantha L.;
- Kashino, Mariah R.;
- Li Ma;
- Younkin, Linda H.;
- Younkin, Samuel G.;
- Younkin, Curtis S.;
- Dincman, Toros A.;
- Howard, Melissa E.;
- Howell, Chanley C.;
- Stanton, Chloe M.;
- Watson, Christopher M.;
- Crump, Michael;
- Vitart, Veronique;
- Hayward, Caroline
Publication type:
Article
Plasma β-Amyloid Peptide, Transforming Growth Factor-β1, and Risk for Cerebral Amyloid Angiopathy.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 903, n. 1, p. 144, doi. 10.1111/j.1749-6632.2000.tb06361.x
By:
- GREENBERG, STEVEN M.;
- CHO, HYUN-SOON;
- O'DONNELL, HEATHER C.;
- ROSAND, JONATHAN;
- SEGAL, ALAN Z.;
- YOUNKIN, LINDA H.;
- YOUNKIN, STEVEN G.;
- REBECK, G. WILLIAM
Publication type:
Article
Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 21, p. 5217, doi. 10.1523/JNEUROSCI.5080-04.2005
By:
- Jankowsky, Joanna L.;
- Melnikova, Tatiana;
- Fadale, Daniel J.;
- Xu, Guilian M.;
- Slunt, Hilda H.;
- Gonzales, Victoria;
- Younkin, Linda H.;
- Younkin, Steven G.;
- Borchelt, David R.;
- Savonenko, Alena V.
Publication type:
Article
Cyclooxygenase-2 inhibition improves amyloid-{beta}-mediated suppression of memory and synaptic plasticity.
Published in:
Brain: A Journal of Neurology, 2008, v. 131, n. 3, p. 651, doi. 10.1093/brain/awn008
By:
- Linda A. Kotilinek;
- Marcus A. Westerman;
- Qinwen Wang;
- Kimberly Panizzon;
- Giselle P. Lim;
- Agnes Simonyi;
- Sylvain Lesne;
- Agnieszka Falinska;
- Linda H. Younkin;
- Steven G. Younkin;
- Michael Rowan;
- James Cleary;
- Roi Ann Wallis;
- Grace Y. Sun;
- Greg Cole;
- Sally Frautschy;
- Roger Anwyl;
- Karen H. Ashe
Publication type:
Article
ABNORMAL LYMPHOCYTE FUNCTION IN TRISOMY 21 *.
Published in:
Annals of the New York Academy of Sciences, 1969, v. 171, n. 2, p. 537, doi. 10.1111/j.1749-6632.1970.tb39363.x
By:
- Mellman, William J.;
- Younkin, Linda H.;
- Baker, David
Publication type:
Article
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase.
Published in:
Human Molecular Genetics, 2004, v. 13, n. 2, p. 159, doi. 10.1093/hmg/ddh019
By:
- Jankowsky, Joanna L.;
- Fadale, Daniel J.;
- Anderson, Jeffrey;
- Xu, Guilian M.;
- Gonzales, Victoria;
- Jenkins, Nancy A.;
- Copeland, Neal G.;
- Lee, Michael K.;
- Younkin, Linda H.;
- Wagner, Steven L.;
- Younkin, Steven G.;
- Borchelt, David R.
Publication type:
Article
Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline.
Published in:
2011
By:
- Yaffe K;
- Weston A;
- Graff-Radford NR;
- Satterfield S;
- Simonsick EM;
- Younkin SG;
- Younkin LH;
- Kuller L;
- Ayonayon HN;
- Ding J;
- Harris TB;
- Yaffe, Kristine;
- Weston, Andrea;
- Graff-Radford, Neill R;
- Satterfield, Suzanne;
- Simonsick, Eleanor M;
- Younkin, Steven G;
- Younkin, Linda H;
- Kuller, Lewis;
- Ayonayon, Hilsa N
Publication type:
journal article
Association of Plasma β-Amyloid Level and Cognitive Reserve With Subsequent Cognitive Decline.
Published in:
JAMA: Journal of the American Medical Association, 2011, v. 305, n. 3, p. 261, doi. 10.1001/jama.2010.1995
By:
- Yaffe, Kristine;
- Weston, Andrea;
- Graff-Radford, Neill R.;
- Satterfield, Suzanne;
- Simonsick, Eleanor M.;
- Younkin, Steven G.;
- Younkin, Linda H.;
- Kuller, Lewis;
- Ayonayon, Hilsa N.;
- Ding, Jingzhong;
- Harris, Tamara B.
Publication type:
Article
Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.
Published in:
Annals of Neurology, 2000, v. 48, n. 2, p. 201, doi. 10.1002/1531-8249(200008)48:2<201::AID-ANA10>3.0.CO;2-X
By:
- Fagan, Anne M.;
- Younkin, Linda H.;
- Morris, John C.;
- Fryer, John D.;
- Cole, Thomas G.;
- Younkin, Steven G.;
- Holtzman, David M.
Publication type:
Article
Amyloid β protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease.
Published in:
Annals of Neurology, 1994, v. 36, n. 6, p. 903, doi. 10.1002/ana.410360616
By:
- Nakamura, Tamiko;
- Shoji, Mikio;
- Harigaya, Yasuo;
- Watanabe, Mitsunori;
- Hosoda, Kenji;
- Cheung, Tobun T.;
- Shaffer, Lillian M.;
- Golde, Todd E.;
- Younkin, Linda H.;
- Younkin, Steven G.;
- Hirai, Shunsaku
Publication type:
Article
Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
Published in:
2005
By:
- Jankowsky, Joanna L.;
- Slunt, Hilda H.;
- Gonzales, Victoria;
- Savonenko, Alena V.;
- Wen, Jason C.;
- Jenkins, Nancy A.;
- Copeland, Neal G.;
- Younkin, Linda H.;
- Lester, Henry A.;
- Younkin, Steven G.;
- Borchelt, David R.
Publication type:
journal article
Heritability of plasma amyloid β in typical late-onset Alzheimer's disease pedigrees.
Published in:
Genetic Epidemiology, 2001, v. 21, n. 1, p. 19, doi. 10.1002/gepi.1015
By:
- Ertekin-Taner, Nilufer;
- Graff-Radford, Neill;
- Younkin, Linda H.;
- Eckman, Christopher;
- Adamson, Jennifer;
- Schaid, Daniel J.;
- Blangero, John;
- Hutton, Michael;
- Younkin, Steven G.
Publication type:
Article

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