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- Title
Protective effect of Viburnum grandiflorum against ultraviolet-B radiation-induced cellular and molecular changes in human epidermal keratinocytes.
- Authors
Liu, Hanjun; Zhang, Haixiu; Dang, Minyan; Lin, Yukiat; Yan, Hui
- Abstract
The aim of the present study was to evaluate the photoprotective potential of Viburnum grandiflorum (VG) against ultraviolet-B radiation-induced responses in HaCaT cells. The HaCaT cells were pretreated with VG prior ultraviolet-B (UVB)-radiation exposure and were further examined for lipid peroxidation, enzymatic antioxidant activity, % reactive oxygen species, DNA damage, mitochondrial membrane potential and for inflammatory, and apoptotic signaling markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interleukin-1 (IL-1), IL-6, cyclooxygenase-2, p53, caspase-3/9, cytochrome-c, Bax, and Bcl-2. The VG pretreatment in UVB exposed cells shows significantly regulated both inflammatory as well as apoptotic signaling cascades. Our findings suggest that VG may be functional against UVB-induced photo-damages.
- Subjects
NF-kappa B; TUMOR necrosis factors; VIBURNUM; KERATINOCYTES; MEMBRANE potential; KERATINOCYTE differentiation; WRINKLES (Skin)
- Publication
Pharmacognosy Magazine, 2021, Vol 17, Issue 73, p200
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/0973-1296.313853