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- Title
Modification of the Ferret Model for Pneumonia From Seasonal Human Influenza A Virus Infection.
- Authors
Brand, J. M. A. van den; Stittelaar, K. J.; Leijten, L. M. E.; Amerongen, G. van; Simon, J. H.; Osterhaus, A. D. M. E.; Kuiken, T.
- Abstract
The article provides information on a study which established a model of human seasonal influenza virus infection that consistently induces pneumonia in ferrets. The study made use of an intra-tracheal route of inoculation and a high viral dose of 109TCID50. It also tested these modified experimental procedures for subtypes H1N1 and H3N2 and for recent and older strains of these subtypes.
- Subjects
ANIMAL models in research; FERRET; IMMUNOHISTOCHEMISTRY; LUNGS; PATHOLOGY
- Publication
Veterinary Pathology, 2012, Vol 49, Issue 3, p562
- ISSN
0300-9858
- Publication type
Article
- DOI
10.1177/0300985811429812