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- Title
The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population.
- Authors
Huang, Yu-qing; Liu, Xiao-cong; Lo, Kenneth; Liu, Lin; Yu, Yu-ling; Chen, Chao-lei; Huang, Jia-yi; Feng, Ying-qing; Zhang, Bin
- Abstract
Purpose: The associations of high-density lipoprotein cholesterol (HDL-C) with mortality are still unclear. We explored the associations of HDL-C with all-cause and cause-specific mortality in an adult population. Methods: Deaths were classified into all-cause, cardiovascular, and cancer mortality. Survival curve, multivariate Cox regression, and subgroup analyses were conducted, and hazard ratio (HR) and 95% confidence interval (CI) were performed. We fitted Cox regression models for all-cause, cardiovascular, and cancer mortality to evaluate their associations with categories of HDL-C (≤ 30, 31– 40, 41– 50, 51– 60 [reference], 61– 70, > 70 mg/dL). Results: A total of 42,145 (20,415 (48.44%) males, mean age 47.12± 19.40 years) subjects were enrolled. At an average follow-up of 97.52± 54.03 months, all-cause, cardiovascular, and cancer mortality numbers were 5,061 (12.01), 1,081 (2.56%), and 1,061 (2.52%), respectively. When compared with the reference group (HDL-C: 51– 60 mg/dL), a U-shaped association was apparent for all-cause mortality, with elevated risk in participants with the lowest (≤ 30 mg/dL) (HR=1.33; 95% CI=1.14– 1.56) and highest (> 70 mg/dL) (HR=1.14; 95% CI=1.02– 1.27) HDL-C concentration. Associations for cardiovascular and cancer mortality were non-linear. An elevated risk for cancer mortality was observed in those with the highest HDL-C concentration (HR=1.06; 95% CI– 0.84– 1.34) compared with the reference group, although it was not statistically significant. The effect of HDL-C on mortality was adjusted by some traditional risk factors including age, gender, race, or comorbidities. Conclusion: A U-shaped association was observed between HDL-C and all-cause mortality among an adult population.
- Subjects
HIGH density lipoproteins; CANCER-related mortality; SURVIVAL analysis (Biometry); MORTALITY; HDL cholesterol
- Publication
Clinical Interventions in Aging, 2020, Vol 15, p1883
- ISSN
1178-1998
- Publication type
Article
- DOI
10.2147/CIA.S271528