We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Potentially Significant Interaction between Efavirenz and Phenytoin: A Case Report and Review of the Literature.
- Authors
Robertson, Sarah M.; Penzak, Scott R.; Lane, Jason; Pau, Alice K.; Mican, JoAnn M.
- Abstract
Although it has not been demonstrated yet, phenytoin is expected to reduce efavirenz exposure through coinduction of cytochrome P450 (CYP) 3A4 and CYP2B6. Conversely, efavirenz has been shown in vitro to inhibit the enzymes responsible for phenytoin metabolism, CYP2C9 and CYP2C19. We report a case in which a potential bidirectional drug interaction between phenytoin and efavirenz resulted in lower-than-expected efavirenz concentrations and elevated phenytoin levels. Therapeutic drug monitoring was used in this case to ensure adequate efavirenz exposure.
- Subjects
PHENYTOIN; CYTOCHROME P-450; ANTICONVULSANTS; MONOOXYGENASES; METABOLISM; DRUG interactions
- Publication
Clinical Infectious Diseases, 2005, Vol 41, Issue 2, pe15
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/431208