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- Title
Identification of the estrogen-active compounds via integrating effect-directed analysis and non-target screening in soils of the northeastern China.
- Authors
Feng, Qiang; Yang, Li; Chen, Jie; Li, Fang; Fang, Fang; Guo, Jinsong; Chen, Zhongli; Shao, Ying
- Abstract
Background: The gaps between estrogenic effect and its effect-active compounds exist frequently due to a large number of compounds that have been reported to induce this effect and the occurrence of pollutants in environments as mixtures. Therefore, identifying the estrogen-active compounds is of importance for environmental management and pollution treatment. In the current study, the effect-directed analysis (EDA) and non-targeted screening (NTS) were integrated to identify the estrogen-active compounds in soils of the rural area with different socioeconomic types (industrial, farming and plantation village) in Northeast China. Results: The cytotoxicity results indicated that the industrial and farming villages showed cytotoxic effects. The detection rates of estrogenic effects for samples of winter and summer were 100% and 87%, respectively. Of which, the effects were found to be stronger in summer than in winter, with significant difference observed from the farming village (0.1–11.3 EEQ μg/kg dry weight). A total of 159 chemicals were detected by NTS. By integrating EDA, triphenyl phosphate (TPhP) and indole were successfully identified from a raw sample and its fraction, explaining up to 19.31% of the estrogen activity. Conclusions: The present study demonstrates that the successful identification of seven estrogen-active compounds in rural areas of northeastern China can be achieved through the combination of effect-directed analysis (EDA) and non-targeted screening (NTS). This finding is beneficial for risk monitoring and pollution management.
- Subjects
CHINA; UNITED States. Economic Development Administration; POLLUTION management; ADAPTIVE natural resource management; POLLUTION monitoring; AGRICULTURAL exhibitions; AGRICULTURE; PLATEAUS
- Publication
Environmental Sciences Europe, 2024, Vol 36, Issue 1, p1
- ISSN
2190-4707
- Publication type
Article
- DOI
10.1186/s12302-024-00885-x